Please write methodology according to STROBE checklist and based on the followin

Please write methodology according to STROBE checklist and based on the following introduction, aims and objectives as well as data collection questionnaire questions .
Celiac Disease (CD) is a genetically predisposed autoimmune disorder marked by a unique serological and histological profile that is brought on by consuming gluten (1). The term “gluten”
refers to a group of proteins that are alcohol-soluble and found in a variety of grains, such as wheat, rye, barley, spelt, and kamut (1). The primary clinical manifestations include extra-intestinal symptoms like anemia, dermatitis herpetiformis, peripheral neuropathy, and osteopenia as well as intestinal symptoms like diarrhea, abdominal distension, and discomfort(2). Patients with CD are treated with a gluten-free diet (GFD) for the rest of their lives.
Continued use of gluten can worsen clinical symptoms, cause more intestinal damage, and raise the risk of developing cancers in the future, such as non-Hodgkin’s lymphoma, esophageal cancer, small intestinal adenocarcinoma, and melanoma(3) However, severe diet compliance involves significant abandonments and lifestyle adjustments that have a negative impact on the overall quality of life (QoL)(4)
A study that is the first and only meta-analysis on the prevalence of CD in Saudi Arabia states that (1.4%) of people have a biopsy-proven CD (5). The “Classic type” of CD marked by malabsorption and gastrointestinal symptoms, is less common than the atypical form, which is frequently asymptomatic and involves extra-intestinal clinical signs, therefore CD is usually ill-defined (6).
The diagnosis of CD should be supported by three main findings: a clinical examination, a small intestinal histopathologic examination, and an examination for serum markers. Important diagnostic tools for celiac disease include oral signs and symptoms such as tooth enamel hypoplasia, oral ulcers, and pain or burning in the tongue.(7)
The field of CD serological testing has advanced significantly in recent years. endomysial antibodies (EMA), Antigliadin antibodies (AGA), and tissue transglutaminase antibodies (tTG) are the most often employed antibodies (8). Early 1980s saw the development of the AGA test, but more current assays may have greater sensitivities and particularities than the now-outdated AGA. In comparison to EMA and tTG test findings, the recently developed deamidated gliadin peptide antibody (DGP) has demonstrated promising performance. However, the information and experience about DGP use are still developing (8)
Some researchers reported that CD was associated with different oral manifestations in children, and the most common oral symptom was Dental enamel defects. Recurrent aphthous stomatitis, multiple caries, delayed dental eruption, and other oral signs that are also linked to celiac disease(9).
The most typical ulcerative condition affecting the oral mucosa is recurrent aphthous stomatitis (RAS). It generally affects healthy people but can also appear clinically in immunocompromised people differently. Numerous local, systemic, immunologic, genetic, allergy, dietary, and microbiological variables, as well as immunosuppressive medications, have been identified as potential causes of RAS, but its exact cause is still unknown. (10)
To the best of the authors’ knowledge, the data regarding celiac disease in the Kingdom of Saudi Arabia is limited, so the present study is prop
Research aim and objectives
Investigate the epidemiological characteristics, pathological features, and clinical manifestations of Celiac Disease in Children and Adults.
To assess the treatment and management approaches and investigate the long-term impact of celiac diseases on oral health.