Respond to the topics below for posting. Support your response with a rationale

Respond to the topics below for posting. Support your response with a rationale and cite the source
For posting and grading guidelines and additional help with discussion assignment, please refer to the On- line discussion rubric located in the evaluation rubrics folder of the course website and to student hand book located within the general information area of the course website.

Please select ONE case study and answer ALL questions for it.

Case Study 1:
A 30 year old woman recently diagnosed with rheumatoid arthritis (RA), complains of general fatigue and weight loss along with symmetric joint welling, stiffness, and pain. The stiffness is more prominent in the morning and subsides during teh day. Laboratory measures reveal an RF of 120 IU/ml (nonreactive, 0 to39 IU/mL; weakly reactive, 40 to 79 IU/ml; reactive, > 80 IU/ml).
Q1. Describe the immunopathogenesis of the joint changes that occur in RA.
Q2. What is the significance of her RF test results?
Q3. How do her complaints of general fatigue and weight loss related to the RA disease process

Case Study 2:
A 38 year old female with a past medical history of significant for lupus erythematosus (SLE) and hypertension, presents to her Primary Care Physician (PCP) for a wellness visit. On physical exam, she is in no distress, VS BP 160/80mmHg (normal takes metoprolol and lisinopril but forgets from time to time) HR 80bpm RR 20/min.
Laboratory results show Hgb 14g/dl, WBC 5.0k, Platelets 160K, Cr. 1.80, eGFR 48ml/min. She denies fevers, chills. Denies diarrhea. The patient is concerned about her elevated Cr and ask the PCP a few questions.
Q1: Compare the etiology of Acute and Chronic Kidney Disease?
Q2: Describe the mechanism for Acute Kidney Injury in Acute Tubular Necrosis.